Laura J. Niedernhofer: search on Z-Library

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1

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Robbins, Paul D., Jurk, Diana, Khosla, Sundeep, Kirkland, James L., LeBrasseur, Nathan K., Miller, Jordan D., Passos, JoÃ£o F., Pignolo, Robert J., Tchkonia, Tamar, Niedernhofer, Laura J.

Journal:

Annual Review of Pharmacology

Year:

2021

File:

PDF, 2.05 MB

2021

2

The Clinical Potential of Senolytic Drugs

Kirkland, James L., Tchkonia, Tamara, Zhu, Yi, Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Journal of the American Geriatrics Society

Year:

2017

Language:

english

File:

PDF, 64 KB

english, 2017

3

Hsp90 inhibitors as senolytic drugs to extend healthy aging

Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.36 MB

english, 2018

4

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

Yousefzadeh, Matthew J., Wilkinson, John E., Hughes, Brian, Gadela, Namrata, Ladiges, Warren C., Vo, Nam, Niedernhofer, Laura J., Huffman, Derek M., Robbins, Paul D.

Journal:

Year:

2020

File:

PDF, 1.11 MB

2020

5

Senotherapeutics for healthy ageing

Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Nature Reviews Drug Discovery

Year:

2018

Language:

english

File:

PDF, 121 KB

english, 2018

6

Heterochronic Parabiosis Approach: is it Possible to Interrupt the Aging Process of the Intervertebral Disc Degeneration? An in vivo Experimental Study

Colangelo, Debora, Robbins, Paul, Nasto, Luigi Aurelio, Niedernhofer, Laura, Pola, Enrico

Journal:

Global Spine Journal

Year:

2016

File:

PDF, 81 KB

2016

7

Nuclear Genomic Instability and Aging

Niedernhofer, Laura J., Gurkar, Aditi U., Wang, Yinsheng, Vijg, Jan, Hoeijmakers, Jan H.J., Robbins, Paul D.

Journal:

Annual Review of Biochemistry

Year:

2018

Language:

english

File:

PDF, 391 KB

english, 2018

8

Hyper telomere recombination accelerates replicative senescence and may promote premature aging

R. Tanner Hagelstrom, Krastan B. Blagoev, Laura J. Niedernhofer, Edwin H. Goodwin, Susan M. Bailey and José N. Onuchic

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.44 MB

english, 2010

9

Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 nd Scripps Symposium on the Biology of Aging

Robbins, Paul D., Niedernhofer, Laura J.

Journal:

Year:

2017

Language:

english

File:

PDF, 82 KB

english, 2017

10

Development of clinical trials to extend healthy lifespan

Justice, Jamie N., Niedernhofer, Laura, Robbins, Paul D., Aroda, Vanita R., Espeland, Mark A., Kritchevsky, Stephen B., Kuchel, George A., Barzilai, Nir

Journal:

Cardiovascular Endocrinology & Metabolism

Year:

2018

File:

PDF, 119 KB

2018

11

ISSLS Prize Winner

Nasto, Luigi A., Seo, Hyoung-Yeon, Robinson, Andria R., Tilstra, Jeremy S., Clauson, Cheryl L., Sowa, Gwendolyn A., Ngo, Kevin, Dong, Qing, Pola, Enrico, Lee, Joon Y., Niedernhofer, Laura J., Kang, Ja

Journal:

Year:

2012

Language:

english

File:

PDF, 2.70 MB

english, 2012

12

Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system

Dong Wang, Nam V. Vo, Gwendolyn A. Sowa, Robert A. Hartman, Kevin Ngo, So Ra Choe, William T. Witt, Qing Dong, Joon Y. Lee, Laura J. Niedernhofer, James D. Kang

Journal:

The Spine Journal

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

13

Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Nasto, Luigi A., Ngo, Kevin, Leme, Adriana S., Robinson, Andria R., Dong, Qing, Roughley, Peter, Usas, Arvydas, Sowa, Gwendolyn A., Pola, Enrico, Kang, James, Niedernhofer, Laura J., Shapiro, Steven,

Journal:

The Spine Journal

Year:

2014

Language:

english

File:

PDF, 996 KB

english, 2014

14

The Role of Cancer Therapy Agents in Intervertebral Disc Degeneration

Luigi A. Nasto, Dong Wang, Cheryl Clauson, Qing Dong, Gwendolyn A. Sowa, Peter Roughley, Paul D. Robbins, Laura Niedernhofer, James D. Kang, Nam Vo

Journal:

The Spine Journal

Year:

2012

Language:

english

File:

PDF, 48 KB

english, 2012

15

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Yi, Doornebal, Ewald J., Pirtskhalava, Tamar, Giorgadze, Nino, Wentworth, Mark, Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D., Tchkonia, Tamara, Kirkland, James L.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.38 MB

english, 2017

16

26. Treatment Using a Therapeutic Peptide Inhibitor Against the Stress Mediator NFkB Delayed Age-Dependent Spinal Degeneration in an Accelerated Aging Mouse Model

Nam Vo, Jeremy Tilstra, Andria Robison, Arydas Usas, Gwendolyn Sowa, Rebecca Studer, Joon Lee, Laura Niedernhofer, James Kang

Journal:

The Spine Journal

Year:

2009

Language:

english

File:

PDF, 133 KB

english, 2009

17

Genetics of extreme human longevity to guide drug discovery for healthy ageing

Zhang, Zhengdong D., Milman, Sofiya, Lin, Jhih-Rong, Wierbowski, Shayne, Yu, Haiyuan, Barzilai, Nir, Gorbunova, Vera, Ladiges, Warren C., Niedernhofer, Laura J., Suh, Yousin, Robbins, Paul D., Vijg, J

Journal:

Nature Metabolism

Year:

2020

File:

PDF, 2.05 MB

2020

18

Genome instability and accelerated aging: The relevance for normal aging and life span extension

Jan H.J. Hoeijmakers, George Garinis, Ingrid van der Pluijm, Jay Mitchell, Jaan-Olle Andressoo, Karin Diderich, Astrid Lalai, Harm de Waard, Dolf Beems, Harry van Steeg, Laura Niedernhofer, Bert van d

Journal:

Year:

2006

Language:

english

File:

PDF, 70 KB

english, 2006

19

Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model

Derek J. Matoka, Veronica Yao, Diana S. Harya, Jennifer L. Gregg, Andria R. Robinson, Laura J. Niedernhofer, Anil V. Parwani, Christoph Maier, Dean J. Bacich

Journal:

Year:

2012

Language:

english

File:

PDF, 1.21 MB

english, 2012

20

Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: Molecules to patients

Laura J. Niedernhofer, Vilhelm A. Bohr, Miriam Sander, Kenneth H. Kraemer

Journal:

Mechanisms of Ageing and Development

Year:

2011

Language:

english

File:

PDF, 610 KB

english, 2011

21

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

Lavasani, Mitra, Robinson, Andria R., Lu, Aiping, Song, Minjung, Feduska, Joseph M., Ahani, Bahar, Tilstra, Jeremy S., Feldman, Chelsea H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny

Journal:

Nature Communications

Year:

2012

Language:

english

File:

PDF, 2.87 MB

english, 2012

22

Attenuation of ataxia telangiectasia mutated signalling mitigates ageâassociated intervertebral disc degeneration

Han, Yingchao, Zhou, ChaoâMing, Shen, Hongxing, Tan, Jun, Dong, Qing, Zhang, Lei, McGowan, Sara J., Zhao, Jing, Sowa, Gwendolyn A., Kang, James D., Niedernhofer, Laura J., Robbins, Paul D., Vo, Nam

Journal:

Year:

2020

File:

PDF, 2.35 MB

2020

23

Nucleotide excision repair deficient mouse models and neurological disease

Laura J. Niedernhofer

Journal:

Year:

2008

Language:

english

File:

PDF, 820 KB

english, 2008

24

Modeling Alzheimer’s disease in progeria mice. An age-related concept

Sharma, Kavita, Darvas, Martin, Keene, C. Dirk, Niedernhofer, Laura J., Ladiges, Warren

Journal:

Pathobiology of Aging & Age-related Diseases

Year:

2018

Language:

english

File:

PDF, 848 KB

english, 2018

25

Mouse models of Fanconi anemia

Kalindi Parmar, Alan D’Andrea, Laura J. Niedernhofer

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2009

Language:

english

File:

PDF, 203 KB

english, 2009

26

Fanconi Anemia (Cross)linked to DNA Repair

Laura J. Niedernhofer, Astrid S. Lalai, Jan H.J. Hoeijmakers

Journal:

Year:

2005

Language:

english

File:

PDF, 736 KB

english, 2005

27

In vivo detection and replication studies of α-anomeric lesions of 2′-deoxyribonucleosides

Amato, Nicholas J., Zhai, Qianqian, Navarro, Diana C., Niedernhofer, Laura J., Wang, Yinsheng

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 3.86 MB

english, 2015

28

Cytoskeleton stiffness regulates cellular senescence and innate immune response in HutchinsonâGilford Progeria Syndrome

Mu, Xiaodong, Tseng, Chieh, Hambright, William S., Matre, Polina, Lin, ChihâYi, Chanda, Palas, Chen, Wanqun, Gu, Jianhua, Ravuri, Sudheer, Cui, Yan, Zhong, Ling, Cooke, John P., Niedernhofer, Laura

Journal:

Year:

2020

File:

PDF, 1.67 MB

2020

29

Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole

Basu, Ashis K., Wood, Michael L., Niedernhofer, Laura J., Ramos, Leilani A., Essigmann, John M.

Journal:

Year:

1993

Language:

english

File:

PDF, 2.11 MB

english, 1993

30

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

Schumacher, Björn, van der Pluijm, Ingrid, Moorhouse, Michael J., Kosteas, Theodore, Robinson, Andria Rasile, Suh, Yousin, Breit, Timo M., van Steeg, Harry, Niedernhofer, Laura J., van IJcken, Wilfred

Journal:

Year:

2008

Language:

english

File:

PDF, 644 KB

english, 2008

31

Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan

Laura J. Niedernhofer, Paul D. Robbins

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2008

Language:

english

File:

PDF, 342 KB

english, 2008

32

Simultaneous Quantification of Methylated Cytidine and Adenosine in Cellular and Tissue RNA by Nano-Flow Liquid Chromatography–Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method

Fu, Lijuan, Amato, Nicholas J., Wang, Pengcheng, McGowan, Sara J., Niedernhofer, Laura J., Wang, Yinsheng

Journal:

Analytical Chemistry

Year:

2015

Language:

english

File:

PDF, 786 KB

english, 2015

33

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, Laura J., Garinis, George A., Raams, Anja, Lalai, Astrid S., Robinson, Andria Rasile, Appeldoorn, Esther, Odijk, Hanny, Oostendorp, Roos, Ahmad, Anwaar, van Leeuwen, Wibeke

Journal:

Year:

2006

Language:

english

File:

PDF, 1002 KB

english, 2006

34

Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice

Scott C. Smith, Andria R. Robinson, Laura J. Niedernhofer, Michal Hetman

Journal:

Neurobiology of Disease

Year:

2012

Language:

english

File:

PDF, 752 KB

english, 2012

35

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, Rafael R., Clauson, Cheryl L., Cho, Joonseok, Lee, Byeong-Chel, McGowan, Sara J., Baker, Darren J., Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.09 MB

english, 2017

36

Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F

Shanbhag, Niraj M., Geschwind, Michael D., DiGiovanna, John J., Groden, Catherine, Godfrey, Rena, Yousefzadeh, Matthew J., Wade, Erin A., Niedernhofer, Laura J., Malicdan, May Christine V., Kraemer, K

Journal:

Neurology: Genetics

Year:

2018

Language:

english

File:

PDF, 507 KB

english, 2018

37

First Reported Patient with Human ERCC1 Deficiency Has Cerebro-Oculo-Facio-Skeletal Syndrome with a Mild Defect in Nucleotide Excision Repair and Severe Developmental Failure

Nicolaas G.J. Jaspers, Anja Raams, Margherita Cirillo Silengo, Nils Wijgers, Laura J. Niedernhofer, Andria Rasile Robinson, Giuseppina Giglia-Mari, Deborah Hoogstraten, Wim J. Kleijer, Jan H.J. Hoeijm

Journal:

The American Journal of Human Genetics

Year:

2007

Language:

english

File:

PDF, 2.32 MB

english, 2007

38

A quantitative assay for assessing the effects of DNA lesions on transcription

You, Changjun, Dai, Xiaoxia, Yuan, Bifeng, Wang, Jin, Wang, Jianshuang, Brooks, Philip J, Niedernhofer, Laura J, Wang, Yinsheng

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 617 KB

english, 2012

39

Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice

Roh, Danny S., Du, Yiqin, Gabriele, Michelle L., Robinson, Andria R., Niedernhofer, Laura J., Funderburgh, James L.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

40

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

Nasto, Luigi A., Robinson, Andria R., Ngo, Kevin, Clauson, Cheryl L., Dong, Qing, St. Croix, Claudette, Sowa, Gwendolyn, Pola, Enrico, Robbins, Paul D., Kang, James, Niedernhofer, Laura J., Wipf, Pete

Journal:

Journal of Orthopaedic Research

Year:

2013

Language:

english

File:

PDF, 1.56 MB

english, 2013

41

NF-κB Negatively Impacts the Myogenic Potential of Muscle-derived Stem Cells

Lu, Aiping, Proto, Jonathan D, Guo, Lulin, Tang, Ying, Lavasani, Mitra, Tilstra, Jeremy S, Niedernhofer, Laura J, Wang, Bing, Guttridge, Denis C, Robbins, Paul D, Huard, Johnny

Journal:

Molecular Therapy

Year:

2012

Language:

english

File:

PDF, 639 KB

english, 2012

42

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms: Table 1.

Burd, Christin E., Gill, Matthew S., Niedernhofer, Laura J., Robbins, Paul D., Austad, Steven N., Barzilai, Nir, Kirkland, James L.

Journal:

The Journals of Gerontology Series A Biological Sciences and Medical Sciences

Year:

2016

Language:

english

File:

PDF, 628 KB

english, 2016

43

Creating the Next Generation of Translational Geroscientists

Newman, John C., Sokoloski, Julie L., Robbins, Paul D., Niedernhofer, Laura J., Reed, May J., Wei, Jeanne, Austad, Steven N., Barzilai, Nir, Cohen, Harvey Jay, Kuchel, George A., Kirkland, James L., P

Journal:

Journal of the American Geriatrics Society

Year:

2019

File:

PDF, 346 KB

2019

44

Fanconi anemia: A paradigm of discovering molecular pathways from patients

Paul R. Andreassen, Laura J. Niedernhofer

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2009

Language:

english

File:

PDF, 101 KB

english, 2009

45

Divide and conquer: nucleotide excision repair battles cancer and ageing

James R Mitchell, Jan HJ Hoeijmakers, Laura J Niedernhofer

Journal:

Current Opinion in Cell Biology

Year:

2003

Language:

english

File:

PDF, 650 KB

english, 2003

46

ERCC1/XPF Removes the 3′ Overhang from Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes

Xu-Dong Zhu, Laura Niedernhofer, Bernhard Kuster, Matthias Mann, Jan H.J Hoeijmakers, Titia de Lange

Journal:

Year:

2003

Language:

english

File:

PDF, 634 KB

english, 2003

47

Systemic clearance of p16 INK4a ‐positive senescent cells mitigates age‐associated intervertebral disc degeneration

Patil, Prashanti, Dong, Qing, Wang, Dong, Chang, Jianhui, Wiley, Christopher, Demaria, Marco, Lee, Joon, Kang, James, Niedernhofer, Laura J., Robbins, Paul D., Sowa, Gwendolyn, Campisi, Judith, Zhou,

Journal:

Year:

2019

Language:

english

File:

PDF, 1.84 MB

english, 2019

48

The Fanconi Anemia Signalosome Anchor

Laura J. Niedernhofer

Journal:

Year:

2007

Language:

english

File:

PDF, 505 KB

english, 2007

49

Deoxyhexanucleotide containing a vinyl chloride induced DNA lesion, 1,N6-ethenoadenine: synthesis, physical characterization, and incorporation into a duplex bacteriophage M13 genome as part of an amber codon

Basu, Ashis K., Niedernhofer, Laura J., Essigmann, John M.

Journal:

Year:

1987

Language:

english

File:

PDF, 1.76 MB

english, 1987

50

Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA

Fu, Lijuan, Guerrero, Candace R., Zhong, Na, Amato, Nicholas J., Liu, Yunhua, Liu, Shuo, Cai, Qian, Ji, Debin, Jin, Seung-Gi, Niedernhofer, Laura J., Pfeifer, Gerd P., Xu, Guo-Liang, Wang, Yinsheng

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 701 KB

english, 2014

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